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Research that has been conducted on mice has shown some validity in possibly using the drug for treating the symptoms of depression, however, the doctors do not believe that it can be used as an anti-depressant unless it is needed in such cases when the other depression meds that are given have failed.

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Tapentadol comes as a tablet and an extended-release (long acting) tablet to take by mouth. The tablets are usually taken with or without food every 4 to 6 hours as needed. If you are taking tapentadol tablets, your doctor may tell you that you may take a second dose as soon as 1 hour after the first dose on your first day of treatment if needed to treat your pain. Do not take extra doses at any other time during your treatment and do not ever take extra doses of the extended-release tablets. The extended-release tablets are taken once every 12 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tapentadol exactly as directed.


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It is available in both immediate-release and extended-release oral tablets. Tapentadol extended-release can also be prescribed to treat severe neuropathic pain associated with diabetic peripheral neuropathy. Tapentadol may be prescribed when alternative pain treatments fail to provide any relief. Immediate-release tapentadol tablets are used to treat acute pain. Extended-release tapentadol tablets are prescribed to provide 24-hour chronic pain relief and should not be used on an as-needed basis for pain. Tapentadol works best if taken at the onset of pain; it may not work as well if pain levels are already high. Tapentadol should only be taken as prescribed.


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